Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.2K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

13.5K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
13.5K
Multiple Comparison Tests01:13

Multiple Comparison Tests

4.0K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
4.0K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.3K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.3K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.4K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.4K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

17.9K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabologenomic profiling of the endemic Australian fungus <i>Aspergillus luteorubrus</i>.

Mycology·2026
Same author

Structural motif search across the protein universe with Folddisco.

Nature biotechnology·2026
Same author

A novel method to select Reference Proteomes in UniProt.

bioRxiv : the preprint server for biology·2026
Same author

Reference-free discovery with barcoded single-cell sequencing.

Nature biotechnology·2026
Same author

FunctionaL Assigning Sequence Homing (FLASH) maps phenotype to sequence with deep and machine learning.

bioRxiv : the preprint server for biology·2026
Same author

Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2.

Nature biotechnology·2026

相关实验视频

Updated: Sep 13, 2025

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K

一个nf-core框架用于替代建模工具的系统比较:多重序列对齐案例研究.

Luisa Santus1,2, Jose Espinosa-Carrasco1, Leon Rauschning1,3

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.

NAR genomics and bioinformatics
|August 1, 2025
PubMed
概括

本研究引入了一个新的nf-core框架,用于在高性能计算 (HPC) 环境中部署和评估多个序列对齐 (MSA) 工具. 该框架旨在简化生物信息学研究人员处理复杂的计算挑战的工具选择和比较.

更多相关视频

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.5K
Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

7.1K

相关实验视频

Last Updated: Sep 13, 2025

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.5K
Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

7.1K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 软件工程 软件工程 软件工程

背景情况:

  • 由于计算复杂性,生物信息学问题往往需要启发式解决方案,导致无数工具没有单一的最佳性能.
  • 识别最佳工具和管理各种方法对用户和开发人员来说都是一个挑战,特别是随着数据量不断增加.
  • 需要标准化框架,以便在高性能计算 (HPC) 环境中无部署和比较工具.

研究的目的:

  • 提出一个试点nf-core框架,以简化多重序列对齐 (MSA) 工具的部署和严格的性能评估.
  • 解决选择和比较计算复杂生物信息学问题的启发式解决方案所面临的挑战.
  • 为超越MSA的更广泛的生物信息学社区提供原则证明.

主要方法:

  • 为MSA软件生态系统量身定制的nf-core框架的开发.
  • 在框架内集成流行的多个序列对齐工具.
  • 设计用于严格的性能评估和MSA方法的比较.

主要成果:

  • 一个试点的nf-core框架,nf-core/多重序列对齐,已经设计和实施.
  • 该框架促进了MSA工具的简化部署和评估.
  • 展示了用于管理和比较启发式生物信息学软件的标准化方法.

结论:

  • nf-core/multiplesequencealign框架为MSA工具的部署和评估提供了一个标准化的解决方案.
  • 该框架是MSA社区的宝贵资源,也是其他生物信息学领域的典范.
  • 它解决了在生物信息学中有效管理和比较启发式计算方法的需求.