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Updated: Sep 13, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Published on: September 20, 2018

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绝缘体EACBE通过调节染色体组织来调节Tcrd基因的V(D) J重组

Yongchang Zhu1,2, Ranran Dai3,4, Hao Zhao5

  • 1Henan Key Provincial Laboratory of Genetic Diseases and Functional Genomics, People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.

Frontiers in immunology
|August 1, 2025
PubMed
概括

一个新的CTCF结合元件,EACBE,通过促进Vδ基因段的使用来调节T细胞受体三角 (TCRδ) 的重新排列. 这一元素也间接影响TCRα (TCRα) 谱的发展.

关键词:
在CTCF中,具有约束力的元素是CTCF.T细胞受体受体的 T 细胞受体.V(D) J的重组组合.染色体活性 染色体活动染色体的架构 染色体的架构

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