lncRNA和miRNA的"分子子"网络:解码肺癌患者的代谢重编程
Mingxiao Li1, Ling Dai1, Simin Chen1
1Medical School, Hunan University of Chinese Medicine, Changsha, China.
Frontiers in oncology
|August 1, 2025
概括
长非编码RNAs (lncRNAs) 和microRNAs (miRNAs) 通过重编程瘤代谢来驱动肺癌的进展. 了解它们的相互作用揭示了肺癌的新诊断和治疗策略.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 遗传学 是一个遗传学.
背景情况:
- 非编码RNAs,包括长非编码RNAs (lncRNAs),在基因调节和细胞功能中起着至关重要的作用.
- lncRNAs是瘤微环境中的关键参与者,影响癌细胞生长,扩散和转移.
- 代谢重编程是癌症的标志,显著影响瘤的进展.
研究的目的:
- 审查lncRNAs和microRNAs (miRNAs) 在肺癌代谢重编程中的作用.
- 阐明参与肺癌代谢的复杂lncRNA-miRNA网络.
- 提供有关代谢脆弱性和治疗机会的机制性见解.
主要方法:
- 对肺癌中lncRNAs,miRNAs和代谢途径研究的文献综述.
- 对竞争的内源RNA (ceRNA) 机制的分析,涉及lncRNAs和miRNAs.
- 检查lncRNAs和miRNAs如何调节核心代谢途径,如葡萄糖,脂质和氨基酸代谢.
主要成果:
- 在肺癌中,lncRNAs和miRNAs显著重编程葡萄糖利用,脂质稳定和氨基酸流量.
- lncRNA-miRNA网络通过代谢变化调节瘤生长,扩散和转移.
- 特定的lncRNA-miRNA相互作用创造了可用于向治疗的代谢漏洞.
结论:
- lncRNAs和miRNAs是肺癌中代谢重编程的关键调节者.
- 针对lncRNA-miRNA网络为肺癌提供了有前途的诊断和治疗途径.
- 对这些相互作用的进一步研究可以揭示肺癌治疗的新策略.
相关概念视频
lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
MicroRNAs
3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
PI3K/mTOR/AKT Signaling Pathway
4.0K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
4.0K
The Nucleolus
9.1K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
9.1K
Metastasis
5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K


