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Updated: Sep 13, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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肠道微生物群和神经骨轴:从孟德尔的随机化和调解分析的见解

Xiuqi Qiao1,2, Yuan Lou1,2, Huan Chen1,2

  • 1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Journal of multidisciplinary healthcare
|August 1, 2025
PubMed
概括

这项研究揭示了肠-神经-骨轴,显示肠道微生物群影响骨矿物质密度 (BMD),可能通过自主神经系统 (ANS). 特定的肠道细菌和心率变化调解了这种联系.

关键词:
门德尔的随机化自主神经系统自主神经系统骨矿物质密度 骨矿物质密度我们的肠道微生物群.心率变化的心率变化.

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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