临床前声和气道损伤模型:一个范围审查
Rahul D Patel1, Nour Awad2, Denzel Ryan D Cruz1,3,4
1College of Medicine, University of Cincinnati Cincinnati Ohio USA.
Laryngoscope investigative otolaryngology
|August 1, 2025
概括
本综述分析了喉外疾病的临床前模型,强调了各种物种,损伤方法和持续时间. 它旨在标准化动物模型中声和气道损伤的未来研究.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 再生医学是一种再生医学.
- 翻译研究是翻译研究.
背景情况:
- 临床前模型对于理解喉外疾病和开发新治疗方法至关重要.
- 目前的研究在临床前模型中缺乏关于物种,损伤机制和研究持续时间的标准化.
- 需要对现有研究进行全面的概述,以指导未来的研究设计.
研究的目的:
- 提供用于声和喉外损伤的临床前模型的当代审查.
- 根据物种,损伤机制和研究持续时间对现有研究进行分类和分析.
- 为解释数据和设计未来临床前研究建立基础框架.
主要方法:
- 对PubMed和Web of Science数据库进行了系统的搜索,对2013年至2023年间发表的研究进行了系统的搜索.
- 包括涉及各种声,气管或喉外损伤和伤口愈合的动物模型的研究.
- 四位独立的评论员选并选择了相关的文章.
主要成果:
- 从1279篇过的文章中确定了197项研究,按物种,持续时间和损伤机制 (MOI) 分类.
- 利波林和老鼠模型是最常见的声和喉外损伤,利波林模型显示出更大的MOI多样性.
- 对于输管损伤,猪模型是普遍存在的,而,老鼠和绵羊模型的使用较少. 研究的持续时间差异很大.
结论:
- 本综述为从临床前声和喉外损伤模型收集和解释数据提供了一个基本框架.
- 这些发现突显了当前临床前研究中的异质性,强调了标准化的必要性.
- 这项工作旨在指导未来的研究设计,以便在该领域进行更一致和可重复的研究.
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