中国复发性复发性多发性硬化症患者睡眠障碍的特征和相关性:一个横截面研究

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Rongrong Wang¹, Tengteng Zhang¹, Han Wang¹

¹Xianyang Hospital of Yan 'an University, Xianyang, China.

Frontiers in neurology

|August 1, 2025

概括

睡眠障碍在复发性缓解性多发性硬化症 (RRMS) 中很常见,并且与焦虑,抑郁和疲劳有关. 解决睡眠问题可能会改善RRMS患者的整体幸福感.

科学领域:

神经学神经学
睡眠医学睡眠医学

背景情况:

睡眠障碍是多发性硬化症 (MS) 患者的一个重要但经常被忽视的问题.
复发性复发性多发性硬化症 (RRMS) 特别在睡眠障碍方面提出了独特的挑战.

研究的目的:

在RRMS患者的睡眠障碍的特征.
在RRMS中分析睡眠障碍与焦虑,抑郁,疲劳和认知障碍之间的关系.

主要方法:

一项涉及35名RRMS患者和35名健康对照者的比较研究.
使用标准化评估,包括匹兹堡睡眠质量指数 (PSQI),雅典失眠量表 (AIS),失眠严重程度指数 (ISI),汉密尔顿焦虑量表 (HAMA),汉密尔顿抑郁量表 (HAMD),修改疲劳影响量表 (MFIS) 和蒙特利尔认知评估 (MoCA).

主要成果:

与对照组相比,RRMS患者在睡眠质量,失眠严重程度,焦虑,抑郁,疲劳和认知功能方面表现出显著差异.
睡眠质量差 (PSQI > 5) 与更高水平的失眠,焦虑和抑郁症有关.
睡眠参数 (PSQI,AIS,ISI,SHAPS,DBAS) 与疲劳,焦虑和抑郁有相关性,有些也与疾病持续时间和日常生活活动相关.

结论:

睡眠障碍,疲劳,焦虑,抑郁和认知障碍在RRMS中很普遍.
在RRMS患者中,各种睡眠评估得分与疲劳,焦虑和抑郁症状之间存在着显著的相关性.

关键词:

焦虑是一种焦虑.认知障碍是一种认知障碍.抑郁抑郁症抑郁症抑郁症是一种疲劳疲劳疲劳疲劳疲劳疲劳复发性缓解性多发性硬化症睡眠障碍睡眠障碍睡眠障碍

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