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原纤维排列和化在动脉样硬化中的进化模式

Chunyang Ma¹, Zhenzhen Jia¹, Shuaiyin Liu¹

¹Key Laboratory of Biomechanics and Mechanobiology ( Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.

Research (Washington, D.C.)

|August 1, 2025

概括

在动脉样硬化 (AS) 中,原纤维的排列随着疾病的进展而被破坏. 在动脉样硬化病变中,这种随机的原蛋白与炎症和化相关,具有诊断潜力.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
材料科学在医学中的科学.

背景情况:

原体的空间布局对于组织力学和细胞调节至关重要.
在动脉样硬化 (AS) 中,原纤维的变化会影响斑块稳定性和血管化,但它们的进展尚不清楚.

研究的目的:

为了研究AS进展过程中原纤维对齐的演变.
为了将原结构的变化与AS的病理特征相关联.

主要方法:

在使用高脂肪饮食的ApoE-/-小鼠中诱导了动脉样硬化.
对大动脉弧原纤维对齐,化标记物和细胞变化的组织学分析每5周进行一次.

主要成果:

原纤维的排列逐渐随机与AS进展.
随机的原纤维与炎症透,光滑肌肉细胞表型切换,骨质基因表达和化有关.

结论:

原纤维排列的变化表明AS病变的存在,位置和进展.
原纤维分析可以帮助评估动脉样硬化斑块的稳定性.
这项研究为在AS诊断和治疗中使用原组合提供了基础.

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