临床挑战和预测性风险因素对COVID-19相关的粘性菌根症的结果
Fardin Ahmadkhani1, Seyed Jamal Hashemi1, Roshanak Daei Ghazvini1
1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iranian journal of pathology
|August 1, 2025
概括
与COVID-19相关的粘膜 (CAM) 是严重的,特别是在不受控制的糖尿病和皮质类固醇使用的情况下. 疾病传播到轨道和中枢神经系统显著增加死亡率,突出显示了早期诊断和干预的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
- 神经学 神经学
- 关键护理医学 关键护理医学
背景情况:
- 粘菌是COVID-19患者的严重并发症,特别是那些患有失控糖尿病和接受皮质类固醇治疗的人.
- 这种真菌感染可以从鼻传播到轨道和中枢神经系统 (CNS),增加发病率和死亡率.
- 了解严重的COVID-19相关粘膜 (CAM) 的风险因素至关重要.
研究的目的:
- 为了确定严重的COVID-19相关粘膜 (CAM) 的临床风险因素.
- 在CAM中确定与疾病严重程度和死亡率相关的结果.
- 专注于疾病进展到轨道和中枢神经系统 (CNS) 的参与.
主要方法:
- 180名确诊的CAM患者被招募并根据疾病程度进行分类:只有鼻腔,鼻腔有轨道,鼻腔有轨道和中枢神经系统参与.
- 收集的数据包括人口统计,临床病史,实验室发现,成像,治疗和结果.
- 统计分析发现了风险因素,疾病进展和结果之间的关联.
主要成果:
- 不受控制的糖尿病 (38%) 和皮质类固醇使用显着与严重的CAM有关.
- 疾病进展到轨道和中枢神经系统的参与分别发生在23.9%和12.8%的患者中.
- 总体死亡率为31%,广泛的疾病与较差的结果和需要积极管理有关.
结论:
- 失控的糖尿病和皮质类固醇治疗是严重CAM的关键风险因素.
- 在CAM中轨道和中枢神经系统的参与与糟糕的结果相关,需要积极的手术干预.
- 早期诊断和及时治疗对于改善CAM患者的生存率至关重要.
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