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Updated: Sep 13, 2025

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在AML附近复制GWAS信号HLA-DQA2使用仅疾病队列和基于外部人口的对照

Rose Laflamme1,2, Véronique Lisi3, Josée Hébert4,5

  • 1Montreal Heart Institute, Montreal, QC, Canada.

Blood neoplasia
|August 1, 2025
PubMed
概括

在HLA-DQA2附近的一个常见的遗传基因变异与急性髓性白血病 (AML) 的风险增加有关. 这一发现在独立队列中复制,也将变异与HLA基因表达联系起来,为AML治疗提供了新的途径.

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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