血清度在预测甲状腺功能障碍症和高血症中的作用
Noriyoshi Takano1, Satoshi Morimoto1,2, Hiroyuki Muraoka3,4
1Division of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
对双相情感障碍的治疗可能会导致甲状腺功能障碍和高血症. 监测0.52mEq/L以上的血清水平对于早期检测和降低风险至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- (Li) 是双相情绪障碍的关键情绪稳定剂.
- 它与甲状腺功能障碍症的关联是公认的,但与血清度的联系尚未完全理解.
研究的目的:
- 为了确定甲状腺功能障碍症和高血症的发病率在Li治疗的患者.
- 评估血清Li水平与这些条件之间的相关性.
- 为了确定血清Li度的预测截止值.
主要方法:
- 在东京妇女医学大学进行了回顾性横截面研究.
- 包括97名患者,估计球膜过率>=45毫升/分钟/1.73米2.
- 排除患有功能障碍的患者.
主要成果:
- 在35.1%的患者中观察到过多甲状腺炎症,在9.3%的患者中观察到高血症.
- 在血清度和两种条件之间发现了显著的正相关性.
- 预测截止值:0.52 mEq/L用于甲状腺功能障碍症,0.62 mEq/L用于高血症.
结论:
- 治疗与偏甲状腺功能障碍症和高血症的高发病率有关.
- 血清度>0.52mEq/L表明风险增加.
- 建议在接受治疗的患者中监测血清和水平.
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