三样质人类白细胞抗原 (HLA) 对痴呆症的保护
Lisa M James1,2,3, Apostolos P Georgopoulos1,2,3,4
1Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, USA.
概括
人类白细胞抗原 (HLA) II类等位基因DRB1*01:01,DRB1*13:02和DRB1*15:01的较高频率与西欧的痴呆症患病率较低相关. 这些常见的等位基因可能会对引起痴呆的病原体提供保护.
科学领域:
- 免疫遗传学 免疫遗传学
- 神经流行病学神经流行病学
背景情况:
- 人类白细胞抗原 (HLA) II类DRB1*13:02已经显示出对痴呆的保护作用.
- 其他常见的HLAII类等位基因在痴呆症患病率中的作用仍在研究中.
研究的目的:
- 评估HLAII类等位基因DRB1*01:01和DRB1*15:01单独和DRB1*13:02的种群频率与痴呆症患病率之间的关联.
- 调查这三种HLA基因对西欧大陆地区痴呆症患病率的综合影响.
主要方法:
- 分析了14个西欧大陆国家的HLAII类等位基因DRB1*01:01,DRB1*13:02和DRB1*15:01的种群频率.
- 统计评估等位基频率与痴呆症患病率之间的相关性,包括特定年龄和时间变化.
主要成果:
- 痴呆的患病率呈指数级下降,随着DRB1*01:01,DRB1*13:02,DRB1*15:01的频率增加,无论是单独的还是组合的 (P < 0.001).
- 这三个等位基因的联合频率解释了痴呆症患病率变异的67%.
- 在65岁以上的人群中发现了与痴呆症患病率的显著关联 (P = 0.004) 和1990-2016年间患病率的变化 (P = 0.006).
结论:
- 三个常见的II类HLA基因 (DRB1*01:01,DRB1*13:02,DRB1*15:01) 在西欧大陆地区显示出对痴呆的保护作用.
- 这些保护性基因的较低种群频率可能与更高的痴呆症患病率有关,可能是由于病原体消除受损.
- HLAII类基因在病原体防御中起着重要作用,影响痴呆风险.
关键词:
痴呆症是一种痴呆症.欧洲欧洲欧洲欧洲欧洲欧洲欧洲哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈人类白细胞抗原持久性抗原是一种抗原.更多相关视频
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