一个微生物群-表观遗传电路控制了肠道表皮中的系统的昼夜计划
Junjie Ma1, Jianglin Zhang1, Zheng Kuang1
1Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States.
Frontiers in systems biology
|August 1, 2025
概括
肠道微生物群编程肠道中的日常节奏,在"工作"和"充电"状态之间交替. 这种微生物调节是由基因素脱乙酶3 (HDAC3) 驱动的,对宿主健康和肠道平衡至关重要.
科学领域:
- 微生物学 微生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 时间生物学 时间生物学
背景情况:
- 肠道微生物群影响宿主的昼夜节律和健康.
- 基斯脱乙酶3 (HDAC3) 在肠道上皮质中同步脂质代谢.
- 肠道中微生物群与昼夜之间相互作用的全部程度尚不清楚.
研究的目的:
- 调查肠道微生物群与昼夜交叉的范围和意义.
- 了解肠道微生物群如何编程节律性的生物过程和上皮功能.
- 阐明HDAC3在微生物群依赖的昼夜节律中的作用.
主要方法:
- 在常规和无细菌小鼠中对基因表达模式的比较.
- 微生物群依赖的昼夜计划的分析.
- 动机丰富分析以确定转录因子参与.
主要成果:
- 肠道微生物群编程了肠道上皮层中各种生物过程 (蛋白质合成,细胞增殖,新陈代谢,免疫) 的节奏表达.
- 在无细菌小鼠中,基因表达节奏减弱,这表明微生物群在结构化宿主基因表达时间中的作用.
- HDAC3通过节律性基因组脱乙烯化驱动大多数微生物群依赖的昼夜计划,通过招募特定的转录因子来差异控制路径.
结论:
- 开始的微生物群通过表观遗传机制"及时"编程肠道上皮功能.
- HDAC3是肠道中微生物群驱动的昼夜节律的关键调解者.
- 这些发现提供了对微生物群-表观遗传相互作用的系统观点,维持宿主恒温.
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