COVID-19对甲状腺功能和格雷夫斯病的心理状态的影响:为期一年的前性研究
Lujia Xu1, Jianbo Zhang1,2, Riping Cong1
1Department of General Practice, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Frontiers in endocrinology
|August 1, 2025
概括
在Graves病患者中,COVID-19感染可能会加剧甲状腺功能障碍和心理困扰. 量身定制的抗甲状腺药物调整和心理干预措施改善了结果,特别是在COVID-19持续时间较长的人群中.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- COVID-19会影响多个器官系统,包括甲状腺.
- 格雷夫斯病 (GDC) 患者容易受到COVID-19感染的并发症的影响.
- 了解共感染患者的甲状腺和心理变化至关重要.
研究的目的:
- 研究COVID-19共感染的格雷夫斯病患者甲状腺功能和心理状况的变化.
- 为了确定与甲状腺功能障碍和COVID-19后心理状况不佳相关的危险因素.
- 评估量身定制的治疗策略的有效性.
主要方法:
- 对90名Graves病患者与COVID-19共感染的潜在随访1年.
- 根据COVID-19持续时间对患者进行分类 (G1: ≤5天,G2: 6-8天,G3: ≥9天).
- 评估甲状腺功能 (FT3,FT4,TSH),COVID-19症状,心理状态 (焦虑,抑郁) 和治疗调整.
主要成果:
- COVID-19症状的数量和持续时间分别是甲状腺功能障碍和心理困扰的独立风险因素.
- G3组 (COVID-19持续时间较长) 显示FT3/FT4比率发生变化,FT4降低,感染后3个月的焦虑/抑郁分数更高.
- 甲状腺功能和心理评分通过调整的抗甲状腺药物治疗 (ATD) 和心理干预在一年内得到改善.
结论:
- 在Graves病患者中,COVID-19可以加快或加剧甲状腺功能障碍和心理困扰.
- 基于FT3/FT4比率优化ATD治疗和实施心理干预是有效的管理策略.
- 较长的COVID-19持续时间与更显著的甲状腺功能改变和心理影响有关.
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