艾滋病毒感染者的白细胞计数和新发糖尿病:一项纵向研究
Sophia C Meyer1, Zoe Klein1, Isabella C Schoepf1,2,3
1University Center for Internal Medicine and Infectious Diseases Service, Kantonsspital Baselland, Department of Clinical Research, University Hospital Basel, University of Basel, Bruderholz, Switzerland.
HIV medicine
|August 1, 2025
概括
高白细胞计数是艾滋病毒感染者糖尿病 (DM) 的独立风险因素,在诊断前10年增加风险与其他已知的因素相似.
科学领域:
- 艾滋病毒 医学 艾滋病毒 医学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 艾滋病毒感染者患上糖尿病 (DM) 的风险增加.
- 慢性炎症,以高白细胞计数为特征,是已知的DM风险在一般人群的贡献者.
- 艾滋病毒感染者的白细胞计数和DM之间的关联尚未得到充分证实.
研究的目的:
- 调查白细胞计数与艾滋病毒感染者新发糖尿病 (DM) 风险之间的关联.
- 确定白细胞计数是否是DM的独立风险因素在这个人群中.
- 为了比较与白细胞计数相关的DM风险与传统和艾滋病毒相关的风险因素.
主要方法:
- 瑞士艾滋病毒队列研究新发性DM (2000-2023) 参与者的分析和匹配的对照.
- 为DM计算单变量和多变量赔率比率 (ORs).
- 评估白细胞数量,传统的DM风险因素,与艾滋病毒相关的因素和潜在的混因素.
主要成果:
- 与对照组相比,在DM病例中观察到较高的白细胞计数 (p < 0.001).
- 在多变量分析中,白细胞五分位数最高与最低的DM几率比率为2.47 (95% CI,1.71-3.57).
- 在诊断前10年,白细胞计数与DM风险显著相关,独立于混因素.
结论:
- 血红细胞数量增加是瑞士艾滋病毒感染者DM的独立风险因素.
- 与高白细胞计数相关的DM风险的大小与传统和与艾滋病毒相关的风险因素相比较.
- 白细胞计数可以预测艾滋病毒感染者在临床诊断前长达十年的DM风险.
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