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身体活动和刺激性肠综合征:进化不匹配在慢性疾病风险中的作用
Makenna B Lenover Moyer1, Mary K Shenk1
1Department of Anthropology, The Pennsylvania State University, State College, University Park, Pennsylvania, USA.
较低的运动活力和较高的BMI增加了易怒肠综合征 (IBS) 的风险. IBS的发展可能涉及运动的长期影响和其他影响能量平衡的因素,而不仅仅是当前的活动水平.
科学领域:
- 流行病学 流行病学
- 人体生理学 人体生理学
- 胃肠病学 胃肠病学
背景情况:
- 不传染性疾病发病率的上升与祖先的身体活动和现代的久坐式生活方式之间的进化不匹配有关.
- 流行病学研究表明,久坐不动的行为与刺激性肠综合征 (IBS) 的风险增加之间存在相关性.
研究的目的:
- 调查身体活动不匹配与发展IBS的风险之间的联系.
- 确定运动活力下降和体重指数 (BMI) 升高是否是IBS的重要预测因素.
主要方法:
- 一个基于人口的宾夕法尼亚州人样本完成了一项关于消化,人口统计和身体活动的在线调查.
- 刺激性肠综合征 (IBS) 的诊断是使用罗马四号标准.
- 二元逻辑回归被用于数据分析,控制年龄和性别.
主要成果:
- 该研究发现,921名参与者中IBS的患病率为28.8%.
- 运动活力较低与IBS风险增加有显著的关联 (OR1.469,p=0.0154).
- 较高的BMI是IBS的强有力的预测因素,超重和肥胖个体的风险明显增加 (分别为1.734和2.062的OR). 体重指数也调解了运动活力和IBS之间的关系.
结论:
- 身体活动不匹配,特别是运动活力低,可能不是IBS的主要驱动因素.
- IBS风险似乎受体力活动 (按BMI表示) 和其他生活方式因素 (如饮食和压力) 的累积影响.
- 运动可能起到保护作用,但其对能量平衡的长期影响,体现在BMI上,对于IBS的发展至关重要.
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