使用间歇性输液血液过来计算绝对血量
Tomoyuki Tanaka1, Tomohiro Matsui1, Keigo Imagawa2
1From the Department of Clinical Engineering, Faculty of Health Care Sciences, Jikei University of Health Care Sciences, Osaka, Japan.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
|August 1, 2025
概括
在透析患者中计算初始绝对血量通过间歇性血液过和相对血量监测来简化. 这种方法提供了一种在治疗期间准确评估血液体积的可访问方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 身体生理学 身体生理学
- 医疗技术 医疗技术 医学技术
背景情况:
- 准确确定绝对血量 (ABV) 对于优化透析治疗至关重要.
- 现有的ABV测量方法可能是复杂的或侵入性的.
研究的目的:
- 评估连续相对血液体积 (RBV) 测量和透析剂输液法用于确定透析患者初始绝对血液体积的有效性.
- 评估这种方法在间歇输液血液过 (iHDF) 的情况下的适用性.
主要方法:
- 该研究采用了一种方法,将RBV监测与间歇性透析剂输注 (稀释) 结合起来,以测量初始和最终绝对血液体积.
- 在接受iHDF的患者中,在五次连续的间歇性透析剂输注期间进行了测量.
- 绝对血液体积的计算是基于在每次稀释期间观察到的相对血液体积变化.
主要成果:
- 在第一到第五次稀释中测量的初始绝对血液体积在4,288 ± 900毫升至3,871 ± 929毫升之间.
- 具体的初始体积从79.5 ± 12.5毫升/公斤到72.7 ± 13.9毫升/公斤不等.
- 从第一个稀释到第五次稀释观察到初始绝对血液体积的统计学上显著下降 (p < 0.05),这表明潜在的累积效应或调整.
结论:
- 间歇输液血液过和相对血液体积测量的联合使用为透析患者确定绝对血液体积提供了简单有效的方法.
- 这种方法为临床医生提供了一个实用的工具,以准确评估和管理患者的流体状况.
相关概念视频
01:09One-Compartment Model: IV Infusion
286
Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
286
01:25Hemodialysis I: Introduction
301
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
301
01:30Continuous Renal Replacement Therapy
146
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
146
01:15Two-Compartment Open Model: IV Infusion
336
A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
336
01:24Hemodialysis II: Procedure and Complications
137
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
137
01:25Hemodialysis III: Nursing Management
189
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
189