在血造干细胞移植受体中治疗腹的方法
Hebah Ghanem1, Geetha Sivasubramanian1, Pranatharthi H Chandrasekar2
1Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, Fresno, California.
Current opinion in infectious diseases
|August 1, 2025
概括
血造干细胞移植 (HSCT) 接受者的腹是具有挑战性的. 多重PCR面板提高了病原体检测,但解释必须考虑移植阶段和临床背景,以有效管理.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 分子诊断学 分子诊断
背景情况:
- 腹是受血造干细胞移植 (HSCT) 患者的常见和复杂并发症.
- 病因有多种,包括粘膜损伤和机会性感染,需要准确的诊断.
研究的目的:
- 审查基于多重PCR的胃肠道诊断在HSCT接受者感染性腹的实用性.
- 提出一个针对移植阶段量身定制的感染性腹评估框架.
主要方法:
- 在HSCT中对多重PCR胃肠道面板的当前文献的综述.
- 在不同移植阶段对病原体分布的分析.
主要成果:
- 多重PCR面板为检测细菌,病毒和原生动物病原体提供了更好的灵敏度和更快的周转时间.
- 这些测试已经确定了以前诊断不足的感染,但无法区分殖民和感染,并可能排除某些病原体 (例如,Strongyloides stercoralis,cytomegalovirus).
- 病原体的患病率随着移植阶段的变化而显著变化,这凸显了需要特定阶段的诊断方法的需要.
结论:
- 综合征性PCR诊断可以提高HSCT患者感染性腹的评估.
- 在移植阶段,免疫状况和临床表现的背景下解释结果可以指导及时和有针对性的管理.
- 非传染性原因和特定的病原体需要额外的调查进行全面的诊断.
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