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工程工厂的全生物为适应气候的农业

Nayanci Portal-Gonzalez¹, Wenbo Wang¹, Wenxing He¹

¹School of Biological Science and Technology, University of Jinan, No. 336, West Road of Nan Xinzhuang, Jinan, Shandong 250022, China.

The ISME journal

|August 1, 2025

概括

微生物组工程创建合成微生物群落 (SynComs) 以适应气候的农业. 这种方法使用生态原理和计算建模来设计可编程植物全生物,以提高可持续性和产量.

科学领域:

微生物生态学微生物生态学
合成生物学合成生物学
计算生物学计算生物学
植物科学植物科学

背景情况:

植物全生物,包括宿主及其相关微生物群,对于植物健康和适应是至关重要的.
气候压力,土壤退化和产量停滞,需要创新的农业解决方案.
微生物组工程提供了一个有前途的策略,以提高植物的弹性和生产力.

研究的目的:

为农业设计合成微生物群落 (SynComs) 提出一个综合框架.
为微生物组工程概述生态原理和合成生物学工具.
突出计算建模在预测和优化 SynCom 性能方面的作用.

主要方法:

对指导微生物组组装的生态原则 (优先效应,基石分类,功能冗余) 的审查.
整合合成生物学工具 (CRISPR干扰,生物传感器,定数感应) 用于可编程的微生物功能.
在SynCom设计和模拟中应用in silico建模 (基因组规模的代谢模型,流量平衡分析,机器学习).
讨论部署策略,包括本地微生物底盘,封装和精确交付.

主要成果:

通过结合生态,合成生物学和计算方法合理设计SynComs的框架.
确定工程可编程微生物功能和植物微生物相互作用的策略.
展示in silico建模的潜力,以预测和优化SynCom组合和性能.
介绍了"可编程全生物体"概念,用于动态的,工程植物微生物伙伴关系.

结论:

通过SynComs和可编程全生物体概念,微生物组工程为农业提供了系统级的方法.
这一跨学科战略为开发具有更好的可持续性和收益稳定性的气候适应性农业提供了路线图.
通过工程微生物伙伴关系,将植物重新定义为可设计的生态系统,提高了适应环境挑战的能力.

关键词:

关键石的分类系统是什么?微生物生态学微生物生态学微生物组工程是微生物组的工程.植物的全生物体.根微生物组是根的微生物组.合成生物学合成生物学合成的微生物群落.系统农业农业

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