甲状腺功能低下症严重程度的范围内的身体组成变化 - 一个系统的审查和元分析
Derrick Kretli-Souza1, Nathalia Elizabete Paulino1, Raiane Aparecida Asevedo1
1Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Avenida Presidente Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Reviews in endocrine & metabolic disorders
|August 1, 2025
概括
临床甲状腺功能低下症 (CH) 和亚临床甲状腺功能低下症 (SCH) 显著影响身体组成,增加BMI,体重和腰围. 在SCH中,这些变化随着甲状腺刺激激素 (TSH) 水平的升高而恶化,可能会增加代谢风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 甲状腺功能低下症,包括临床 (CH) 和亚临床 (SCH) 形式,是一种常见的内分泌疾病.
- 甲状腺激素水平的变化被怀疑会影响身体组成和代谢参数.
- 现有研究对CH和SCH对人类测量指标的具体影响提出了多样化的发现.
研究的目的:
- 系统地审查和元分析CH和SCH对关键人体参数的影响.
- 量化甲状腺刺激激素 (TSH) 在SCH内的不同水平对人体构成的影响.
- 为了比较CH和SCH对身体组成的影响.
主要方法:
- 观察性研究的系统审查和元分析.
- 在主要的科学数据库中进行了搜索 (PubMed,科学网,Scopus,EMBASE).
- 包括38项涉及49427人的研究,分析效果大小 (ES) 和95%置信区间 (CI).
主要成果:
- CH显示BMI (ES=1.092) 和体重 (BW) (ES=0.897) 大幅增加,腰围 (WC) (ES=0.759) 和脂肪质量 (ES=0.609) 中度增加.
- SCH显示BMI (ES=0.596) 和BW (ES=0.712) 中适度增加,WC增加很小 (ES=0.298) 和脂肪质量变化可以忽略不计 (ES=-0.055).
- 在SCH中,较高的TSH水平与对BMI,BW和WC更大的不良影响相关;在接近正常的TSH水平 (4.0-4.9mIU/L) 上没有观察到显著变化.
结论:
- 无论是CH还是SCH都与身体组成的不利变化有关,特别是BMI,BW和WC,这有助于代谢风险.
- 在SCH中对身体组成的影响随着TSH水平的上升而升级.
- 在女性和有症状的个体中,甲状腺功能低下症和身体组成变化之间观察到更强烈的关联.
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