表观遗传年龄加速和精神疾病之间的关联:双向的门德尔随机化研究
1The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. hongyanggang@wmu.edu.cn.
European archives of psychiatry and clinical neuroscience
|August 1, 2025
概括
表观遗传衰老加速 (EAA) 和精神疾病有双向关系. 一些精神疾病可能加速生物衰老,增加疾病风险,而另一些则对EAA表现出保护作用.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 表观遗传衰老加速 (EAA) 是生物衰老的生物标志物.
- EAA与精神疾病之间的因果关系尚未得到充分理解.
- 遗传和环境因素影响衰老和精神健康.
研究的目的:
- 调查EAA的多项测量和十种精神疾病之间的双向因果关系.
- 澄清EAA是否影响精神疾病或反之.
主要方法:
- 双向的双样本孟德尔随机化 (MR) 分析.
- 利用来自欧洲大型祖先队伍的全基因组关联研究 (GWAS) 总结统计数据.
- 进行敏感性分析以确保调查结果的可靠性.
主要成果:
- Age加速 (PhenoAA) 增加了注意力缺陷多动症障碍 (ADHD) 的风险.
- 汉努姆加速衰老 (HannumAA) 显示出对强迫症 (OCD) 的保护作用.
- 自闭症谱系障碍 (ASD) 与内在表观遗传年龄加速 (IEAA) 的降低有关,而主要抑郁症 (MDD) 增加了HannumAA和IEAA.
结论:
- 精神疾病和生物衰老过程是双向相关的.
- 早期的心理健康状况可能会加速表观遗传衰老,并增加与年龄有关的疾病的风险.
- 研究结果表明,精神疾病是衰老的危险因素,强调了对精神病患者群体进行针对衰老的干预的必要性.
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