一种基于药物的模型,用于预测老年诊所门诊患者的低血症
Anne Claire B van Orten-Luiten1,2, Elske M Brouwer-Brolsma3, André Janse4,5
1Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands. wout.vanorten-luiten@wur.nl.
European journal of clinical pharmacology
|August 1, 2025
概括
一个新的基于药物的模型可以帮助预测低血症,这是一种与老年人跌倒和认知问题相关的疾病. 这种工具有助于老年门诊患者的早期诊断,防止有害的治疗.
科学领域:
- 老年医学 老年医学
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- 老年人的慢性低血症与诸如跌倒,骨折和认知障碍等不良结果有关.
- 在门诊情况下诊断低血症是很困难的,因为非特异性症状.
- 现有的低血症研究主要集中在住院患者身上,对门诊患者的数据有限.
研究的目的:
- 开发一种基于药物的非侵入性模型,用于预测老年人老年门诊诊所的低血症.
- 在这个特定的患者群体中确定低血症的关键预测因素.
主要方法:
- 分析了来自2181名55岁及以上的门诊患者的横截面数据.
- 后勤回归模型 (逐步向后和LASSO) 用于选择预测因素.
- 预测因素包括多药,特定药物组,性别,年龄和BMI;通过引导和ROC曲线分析进行内部验证.
主要成果:
- 低血症的患病率为10.5%,尤其是女性的患病率更高.
- 综合性,年龄,BMI,多药和11种药物组的复杂模型实现了0.75.5的AUC.
- 仅使用多种药物的更简单模型显示出有限的预测性能 (AUC = 0.64).
结论:
- 一种基于药物的模型有效预测老年门诊患者的低血风险.
- 早期识别低血症可以防止误诊和相关的不良事件.
- 开发的模型为临床实施需要进一步改进.
更多相关视频
相关概念视频
Acute Kidney Injury VI: Nursing Management
61
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
61
Regulation of Sodium and Potassium
851
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
851
Antihypertensive Drugs: Potassium-Sparing Diuretics
773
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
773
Nephrotic Syndrome III : Nursing Management
45
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
45
Antihypertensive Drugs: Action of Diuretics
874
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
874
Heart Failure VI: Adjunct Therapies
28
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
28


