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Updated: Sep 8, 2025

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry

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高通量单克隆抗体片映射使用15秒的HPLC梯度与周期性离子移动性质谱相结合

Devin M Makey1, Brandon T Ruotolo1, Robert T Kennedy1,2

  • 1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Analytical chemistry
|August 1, 2025
PubMed
概括

这项研究引入了一种使用循环离子流动性质谱学 (LC-cIM-MS) 快速液体色谱的快速基映射技术,用于分析单克隆抗体 (mAbs). 该方法显著提高了关键质量属性 (CQA) 分析的吞吐量,加速了治疗开发.

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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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