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确定新的伪基因RPL7P1导向网络作为药物向对抗感染的药物目标,先前存在的糖尿病

Jiajun Chen¹, Chenxi Li¹, Ying Wang²

¹School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China.

Integrative biology : quantitative biosciences from nano to macro

|August 1, 2025

概括

这项研究确定了RPL7P1作为糖尿病与感染 (DCI) 的关键伪基因,揭示了它在疾病途径和潜在治疗点中的作用. 这些发现突出了伪基因.

科学领域:

基因组学和分子生物学
计算生物学和生物信息学
传染病的发病原因传染病的发病原因

背景情况:

与感染 (DCI) 并存的糖尿病显著提高了患者严重结局和死亡的风险.
在DCI的发病过程中,非特征化伪基因 (如RPL7P1) 的作用在很大程度上仍未被探索.

研究的目的:

调查假基因RPL7P1在与感染 (DCI) 同时存在的糖尿病病变发生过程中的潜在作用.
确定与DCI中RPL7P1相关的分子机制和潜在的治疗点.

主要方法:

利用ENCODE数据集用于基因识别和NetworkAnalyst用于基因网络分析和扩展.
使用药物重新定位,NHGRI GWAS目录用于疾病验证,以及Cytoscape用于网络可视化.
综合单细胞分析和RNA修饰分析 (m6A),以阐明分子相互作用.

主要成果:

RPL7P1通过隔离hsa-miR-144-3p,与IGF2BP2蛋白相互作用,并与ATP6V1E1RNA交叉调节DCI.
确定了内皮细胞作为潜在的信号连接;发现了RPL7P1的m6A修饰和在cuproptosis中的作用.
针对RPL7P1网络的治疗剂在糖尿病患者的感染管理中表现出潜力.

结论:

伪基因RPL7P1在DCI的发病过程中发挥着重要作用,突显了伪基因在复杂疾病中的重要性.
提供了对DCI表观遗传调节和cuproptosis的新见解,并确定了潜在的治疗策略.
多学科的方法对于理解复杂的共存疾病机制和开发有效的治疗方法至关重要.

关键词:

在RPL7P1中,使用RPL7P1.伴随性疾病发生率.糖尿病糖尿病患者糖尿病患者毒品毒品毒品是一种药物.感染的感染感染.一个伪造的伪造物.一个单细胞的单细胞.

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