心血管和大动脉波反射响应晚上暴饮暴喝酒的反应
Grant S Thivierge1,2,3, Ian M Greenlund1,4,5, Jeremy A Bigalke1,4,6,7
1Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan, United States.
概括
晚上大量饮酒会急剧增加心率和大动脉脉动负荷. 第二天早上,它提高了心率,大动脉脉动负荷和大动脉增大指数,突出了心血管风险.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 酒精代谢及其影响
背景情况:
- 晚上大量饮酒与睡眠障碍和自主性失调有关.
- 过度饮酒对早晨后动脉硬和大动脉波反射的影响尚不清楚.
研究的目的:
- 研究晚上暴饮暴酒对心血管参数的急性影响.
- 为了确定早上饮酒过度饮酒对动脉硬和大动脉波反射的影响.
主要方法:
- 采用了一种随机,交叉,流体控制的研究设计.
- 参与者接受了过度饮酒和流体控制方案.
- 测量了心血管反应,包括心率 (HR),动脉-大腿脉冲波速 (cfPWV),大动脉增大指数 (AIx) 和大动脉脉动负荷 (APL).
主要成果:
- 晚上饮酒急剧增加了HR和APL.
- 在第二天早上,饮酒过度导致HR,APL增加,与液体控制相比,AIx (AIx@75) 正常化.
- 在急性和早晨酒精暴露后,cfPWV保持不变.
结论:
- 晚上大量饮酒会导致立即的心血管变化,并在第二天早上持续影响.
- 过度饮酒后HR,APL和AIx@75的增加表明心血管风险增加.
- 这些发现阐明了与过度饮酒与不良心血管结果相关的生理途径.
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