肺瘤提高了DETECT分数:对肺高血压查和系统性硬化症诊断的影响
Gesa M Sauer1, Florian Käs1, Carmen-Marina Mihai1
1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Rheumatology (Oxford, England)
|August 1, 2025
概括
综合性肺纤维化和肺气 (CPFE) 和全身性硬化 (SSc) 患者的肺气与肺高血压查的DETECT分数较高有关. 这些发现支持DETECT算法.
科学领域:
- 肺部医学 肺部医学
- 类风湿病学 类风湿病学
- 放射学 放射学是一门学科.
背景情况:
- 结合性肺纤维化和肺气 (CPFE) 与系统性硬化症 (SSc) 的不良结果有关.
- 肺功能测试 (PFT) 异常在CPFE和肺气中很常见.
- 肺高血压的查算法,如DETECT算法,通常包含PFTs.
研究的目的:
- 评估CPFE和肺气是否会影响DETECT算法在识别需要右心导管治疗 (RHC) 的SSc患者的准确性.
- 评估CPFE和肺气与DETECT分数的关联,包括阳性和假阳性结果.
主要方法:
- 对SSc患者的回顾性分析,可获得胸部CT扫描和DETECT得分数据.
- 排除具有先前存在的肺高血压的患者.
- 使用回归模型分析了CPFE,ILD,肺气和DETECT得分参数之间的关联,并对共变量进行了调整.
主要成果:
- 在550名符合条件的SSc患者中观察到CPFE的7%的患病率.
- 患有肺气或CPFE的患者的DETECT得分明显更高,经常超过RHC转诊值.
- 肺和CPFE,但不仅仅是间歇性肺病 (ILD),预测了积极的DETECT得分;然而,这两者都与虚假阳性结果无关.
结论:
- 在SSc患者中,CPFE或肺气的存在与DETECT得分呈阳性的可能性更高.
- DETECT算法在SSc患者的肺高血压查中证明了其有效性,这些患者有CPFE或肺气.
- 这些发现支持在SSc亚组中继续使用DETECT算法,这些亚组的特征是纤维化和肺突发性肺部变化.
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