在急性胰腺炎随机对照试验中对疼痛评估领域的系统审查
Nejo Joseph1,2, Louise Kuhlmann3, James Lucocq4
1Department of Surgery, University of Auckland, Auckland, New Zealand.
Pancreas
|August 1, 2025
概括
大多数急性胰腺炎 (AP) 疼痛管理的随机对照试验 (RCT) 使用简单的疼痛强度工具. 需要多维疼痛评估,以便在临床实践和未来的试验中进行更好的评估.
科学领域:
- 胃肠病学 胃肠病学
- 疼痛管理 疼痛管理
- 临床试验 临床试验
背景情况:
- 急性胰腺炎 (AP) 疼痛管理研究依赖于随机对照试验 (RCT).
- 有效的疼痛评估对于评估AP治疗疗效至关重要.
研究的目的:
- 评估用于AP疼痛管理的RCT中使用的疼痛评估领域.
- 在AP临床试验中识别疼痛评估方法的差距.
主要方法:
- 对专注于AP疼痛管理的RCT进行系统审查.
- 对疼痛评估领域,方法,救援止痛和不良影响的研究分析.
主要成果:
- 审查了16个RCT (1984-2024,1016名患者).
- 15个试验使用了单维工具 (VAS,NRS);一个使用了多维m-BPI.
- 在疼痛测量,止痛疗效,救援策略和不良事件报告 (恶心,吐,肠道变化) 中存在显著差异.
- 报告没有关于生活质量或身体/心理功能的数据.
结论:
- 目前的RCT主要使用单维疼痛评估,无法捕捉疼痛的复杂性.
- 对于AP特定的多维疼痛评估工具有极大需求.
- 改进的评估工具将增强临床实践和AP疼痛管理的未来研究.
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