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一个 LAG 接吻会让T细胞变冷

Thomas T Xu1, Shiv Pillai1

  • 1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Science immunology
|August 1, 2025
PubMed
概括

淋巴细胞激活基因3 (LAG-3) 通过破坏CDε-Lck凝结物来抑制CD4+T细胞激活. 该机制强调了LAG-3作为治疗癌症和自身免疫性疾病的关键治疗目标.

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