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Updated: Sep 13, 2025

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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Published on: March 1, 2024

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数学建模表明14-3-3蛋白调节RAF悖论激活

Gaurav Mendiratta1, Kodye Abbott2, Yao-Cheng Li3

  • 1Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America.

PLoS computational biology
|August 1, 2025
PubMed
概括

RAF抑制剂悖论激活 (PA) 被14-3-3蛋白质放大. 根据数学建模和实验,这些蛋白质稳定了RAF信号,可能诱导PA并导致药物耐药性.

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