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Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

18.2K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
18.2K
First Law: Particles in One-dimensional Equilibrium01:10

First Law: Particles in One-dimensional Equilibrium

7.1K
Newton's first law of motion states that a body at rest remains at rest, or if in motion, remains in motion at constant velocity, unless acted on by a net external force. It also states that there must be a cause for any change in velocity (a change in either magnitude or direction) to occur. This cause is a net external force. For example, consider what happens to an object sliding along a rough horizontal surface. The object quickly grinds to a halt, due to the net force of friction. If...
7.1K
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

3.1K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.1K
Phase Transitions: Sublimation and Deposition02:33

Phase Transitions: Sublimation and Deposition

18.0K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
18.0K
Unsoundness of Aggregate due to Volume Change01:26

Unsoundness of Aggregate due to Volume Change

179
Unsoundness in aggregates due to volume changes is primarily caused by the physical alterations aggregates undergo, such as freezing and thawing, thermal changes, and wetting and drying. Unsound aggregates, when subjected to these changes, result in volume change upon disintegration. This, in turn, contributes to the deterioration of concrete, including scaling, pop-outs, and cracking. Particular types of aggregates, such as porous flints, cherts, and those containing clay minerals, are...
179
First Law: Particles in Two-dimensional Equilibrium01:18

First Law: Particles in Two-dimensional Equilibrium

5.2K
Recall that a particle in equilibrium is one for which the external forces are balanced. Static equilibrium involves objects at rest, and dynamic equilibrium involves objects in motion without acceleration; but it is important to remember that these conditions are relative. For instance, an object may be at rest when viewed from one frame of reference, but that same object would appear to be in motion when viewed by someone moving at a constant velocity.
Newton's first law tells us about...
5.2K

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相关实验视频

Updated: Sep 13, 2025

Excitonic Hamiltonians for Calculating Optical Absorption Spectra and Optoelectronic Properties of Molecular Aggregates and Solids
08:04

Excitonic Hamiltonians for Calculating Optical Absorption Spectra and Optoelectronic Properties of Molecular Aggregates and Solids

Published on: May 27, 2020

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一个粗的MD模型,用于PolyQ聚合中的混乱到秩序转换.

Maurice Dekker1, Mark L van der Klok1, Erik Van der Giessen1

  • 1Zernike Institute for Advanced Materials, University of Groningen, Groningen 9747 AG, The Netherlands.

Journal of chemical theory and computation
|August 1, 2025
PubMed
概括
此摘要是机器生成的。

在神经退行性疾病中的多重胺 (polyQ) 聚合被用分子动力学建模. 较长的多Q链表现出更快的聚合,揭示了诸如β片延长等关键机制.

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Assembly and Characterization of Polyelectrolyte Complex Micelles
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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Automating Aggregate Quantification in Caenorhabditis elegans

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相关实验视频

Last Updated: Sep 13, 2025

Excitonic Hamiltonians for Calculating Optical Absorption Spectra and Optoelectronic Properties of Molecular Aggregates and Solids
08:04

Excitonic Hamiltonians for Calculating Optical Absorption Spectra and Optoelectronic Properties of Molecular Aggregates and Solids

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Assembly and Characterization of Polyelectrolyte Complex Micelles
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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Automating Aggregate Quantification in Caenorhabditis elegans
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Automating Aggregate Quantification in Caenorhabditis elegans

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科学领域:

  • 生物物理学的生物物理.
  • 神经科学是一个神经科学.
  • 计算生物学 计算生物学

背景情况:

  • 多聚胺 (polyQ) 聚合与亨廷顿病等神经退行性疾病有关.
  • 了解多Q聚合机制对于治疗开发至关重要.

研究的目的:

  • 开发和验证用于polyQ聚合的粗粒度分子动力学模型.
  • 探索各种聚合途径和序列长度的影响.

主要方法:

  • 用原子学数据和实验校准的粗粒度分子动力学模拟.
  • 对相互作用参数的系统变化,以探索聚合途径.
  • 种子聚合模拟用于分析生长机制.

主要成果:

  • 观察到的聚合途径从核增长到液态到固态相位过渡.
  • 粉样蛋白的生长主要是通过β片延长发生的,并且还注意到了硬质拉链.
  • 较长的多Q序列 (Q48) 的聚合速度明显快于较短的 (Q23).

结论:

  • 开发的模型为研究多Q聚合提供了一个多功能框架.
  • 链条长度是影响多Q聚合动学的关键因素.
  • 该模型为更广泛的聚合机制和序列变化提供了洞察力.