在儿童感染SARS-CoV-2后的抗NMDA受体脑炎
Li-Ping Huang1, Chyuan'an Lai2, Qing Kang3
1Department of Pediatrics, Taizhou Hospital of Zhejiang Province, No. 150 Ximen Street, Linhai City, Zhejiang Province, China.
Diagnostic microbiology and infectious disease
|August 1, 2025
概括
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可能引发抗N-甲基-d-酸盐 (anti-NMDA) 受体脑炎. 早期的神经抗体测试对于在COVID-19后出现神经症状的患者迅速免疫治疗至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 新型冠状病毒疾病2019 (COVID-19) 与各种神经系统并发症有关.
- 抗N-甲基-d-酸盐 (anti-NMDA) 受体脑炎是一种严重的自身免疫神经系统疾病.
- 区分抗NMDA受体脑炎与后COVID-19综合征对于适当的管理至关重要.
研究的目的:
- 在COVID-19之后报告抗NMDA受体脑炎的病例.
- 突出这些患者早期诊断和免疫治疗的重要性.
- 为了防止误诊作为COVID-19后的长期影响.
主要方法:
- 对三名被诊断患有COVID-19后抗NMDA受体脑炎的儿科患者的回顾性分析.
- 包括临床数据:人口统计,表现,实验室,成像,电生理学,治疗和结果.
- 对SARS-CoV-2 IgG和抗NMDAR IgG抗体的脑脊髓液的分析.
主要成果:
- 患者最初出现的非特异性症状归因于COVID-19后综合征.
- 发作发作的延迟,言语和运动异常以及神经精神病症状发生.
- 诊断通过CSF单细胞升高,CSFSARS-CoV-2 IgG阳性和抗NMDAR IgG的确诊.
- 用免疫疗法 (IVIG和皮质类固醇) 治疗导致整体康复.
结论:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染可能引发抗NMDAR脑炎.
- 建议进行神经抗体测试,以检测SARS-CoV-2感染后的神经症状.
- 早期免疫疗法改善了COVID-19后抗NMDAR脑炎患者的结果.
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