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在喉癌中唾液和组织CD44表达

Maria Rita Bianco¹, Federico Occhiuzzi¹, Cosimo Galletti²

¹Department of Health Science, Otolaryngology, University of Catanzaro, 88100 Catanzaro, Italy.

American journal of otolaryngology

|August 1, 2025

概括

唾液中的CD44水平与瘤CD44表达在喉癌患者中相关. 这一发现表明唾液CD44 (CD44sol) 可能成为头癌的新型诊断和预后生物标志物.

科学领域:

在瘤学瘤学.
生物标志物发现发现
头部和部癌症研究研究

背景情况:

喉癌是一种常见的头癌,经常在晚期诊断出来.
对于喉癌的可靠的诊断和预后生物标志物有着至关重要的需求.
CD44是一种细胞表面糖蛋白,与癌症进展有关.

研究的目的:

调查喉瘤组织中CD44表达与唾液中可溶性CD44 (CD44sol) 水平之间的相关性.
评估瘤CD44表达和唾液CD44sol作为喉癌的诊断和预后标记物的潜力.

主要方法:

该研究包括74名被诊断患有喉癌的患者.
使用免疫组织化学技术量化瘤组织CD44表达.
唾液中的CD44sol水平通过酶相关免疫吸收试验 (ELISA) 进行测量.

主要成果:

在瘤组织中的CD44表达和唾液中的CD44sol水平之间观察到显著的统计相关性.
在诊断时,CD44瘤表达是低度瘤和淋巴结转移的预后生物标志物.
阳性唾液CD44sol水平预测了低度瘤,特定的瘤部位和淋巴结转移.

结论:

这项研究是第一个在唾液中CD44sol水平和瘤组织中CD44表达在喉癌中之间建立显著相关性的研究.
唾液CD44sol显示为诊断和预测喉癌的预后的非侵入性生物标志物具有前途.
瘤组织和唾液中的CD44表达具有改善喉癌管理的潜力.

关键词:

生物标志物生物标志物 CD4444 是一个CD44 在CD44sol中使用.喉癌是一种喉癌.预测预后预测预测这是唾液的唾液.

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