试管婴儿补充剂:有效性,效率,安全性和额外成本 - SIFES-MR的立场声明
Danilo Cimadomo1, Mauro Cozzolino2, Andrea Busnelli3
1Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy; IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Rome, Italy.
概括
试管婴儿补充剂需要进行批判性评估. 虽然有些,如PGT-A,在特定情况下显示出希望,但其他则缺乏证据或构成风险. 基于证据的实践和明确的患者沟通对于辅助生殖技术至关重要.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
背景情况:
- 试管婴儿补充剂是标准程序的附加品.
- 它们的有效性,安全性和成本效益差异很大.
- 基于证据的选择对于患者护理至关重要.
研究的目的:
- 批判性地评估试管婴儿的补充.
- 提供基于当前证据和专家共识的建议.
- 为了指导临床实践和患者咨询.
主要方法:
- 多学科专家小组在两年内达成共识.
- 修订国际指导方针 (ESHRE,HFEA,ISAR,ASRM) 的内容.
- 文献审查和德尔菲共识工作流程.
主要成果:
- 预植入前遗传测试 (PGT-A) 显示出在特定人群中具有潜力.
- 其他附加程序缺乏足够的证据或引发安全问题.
- 不建议进行子宫内膜受体测试和mtDNA负载测量.
结论:
- 在辅助生殖技术 (ART) 中强调基于证据的实践.
- 强调需要明确的患者沟通和咨询.
- 倡导进一步研究和对IVF补充剂的监管监督.
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