UPF1通过破坏CD52mRNA的稳定来减轻质瘤中的CD8+T细胞耗尽

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Junwei Duan1, Long Zhao1, Jie Duan1

  • 1Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Tissue & cell
|August 1, 2025
PubMed
概括

在耗尽的CD8+T细胞中,UPF1的下调与质瘤的进展相关. 恢复UPF1通过减少CD52增强抗瘤免疫力,改善质瘤患者和小鼠模型的存活率.

关键词:
CD52 mRNA 的稳定性CD8(+) T细胞耗尽质瘤是一种质瘤.免疫检查站检查站在 UPF1 的情况下.

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