相关实验视频

Updated: Sep 13, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

呼吸学分析简化了对结直肠癌的个性化查

Yongyan Ji¹, Jian Chen¹, Yongqian Liu¹

¹Department of Environmental Science & Engineering, Fudan University, Shanghai, 200438, PR China.

|August 1, 2025

概括

一种新的呼吸测试通过分析特定的挥发性有机化合物 (VOC) 来检测结直肠癌 (CRC). 这种非侵入性方法对早期CRC检测和查高风险个体有希望.

科学领域:

代谢学代谢学代谢学
癌症的诊断癌症的诊断
生物标志物发现发现

背景情况:

大肠直肠癌 (CRC) 是癌症死亡的主要原因.
早期检测显著提高了患者的生存率.
目前用于CRC的非侵入性诊断试验缺乏可靠性.

研究的目的:

为了识别表明结直肠瘤发生的代谢干扰.
开发一种用于检测CRC的非侵入性呼吸试验.
评估CRC的排气挥发性有机化合物 (VOC) 的诊断性能.

主要方法:

结合转录学,呼吸分析和癌瘤组织和呼气代谢物的临床分析.
鉴定出失调的短链脂肪酸和化物代谢.
开发了一种基于质谱的针对特定VOC的向测试.

主要成果:

酸和黄油酸的显著耗尽,在CRC患者的呼气中增加了propanal和hexanal.
开发的呼吸测试显示了高灵敏度 (88.2%105.2%) 和低检测极限 (<0.25 ng/L).
基于VOC的诊断模型实现了0.89的AUC,超过了血清标志物 (AUC0.69).

结论:

呼出的VOC分析显示了与结直肠瘤发生相关的代谢变化.
使用特定的VOC进行的向呼吸试验显示了CRC的高诊断准确性.
这种非侵入性呼吸试验具有早期CRC检测和人口查的潜力.

关键词:

呼吸学是一种呼吸学.结肠直肠癌是一种癌症.非侵入性诊断是一种非侵入性诊断.挥发性有机化合物挥发性有机化合物

更多相关视频

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

相关概念视频

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...