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Updated: Jun 24, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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作为PGC-1α转录激活剂的ZLN005,在永久性闭塞模型中,在心肌梗塞后加剧心脏功能

Taiga Okumura1, Takahiro Sasaki1, Yoshiki Kuse1

  • 1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.

Biochemical and biophysical research communications
|August 1, 2025
PubMed
概括

作为PGC-1α激活剂的ZLN005,通过降低心脏功能和线粒体ATP产生,恶化了心肌梗塞 (MI) 的结果. 这项研究表明,持续服用ZLN005会加剧心脏病发作.

关键词:
线粒体中的线粒体.心肌梗塞的心脏病发作它们是PGC-1α.ZLN005 这是一个很好的例子.

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