身体活动与新诊断患有多发性硬化症的人的疲劳有关
Trinh Lt Huynh1, Peixuan Zheng2, Brenda Jeng2
1Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Multiple sclerosis and related disorders
|August 1, 2025
概括
轻度体力活动 (LPA) 与新诊断的多发性硬化症 (MS) 患者的疲劳减少有关. 这一发现表明,LPA干预可以帮助管理早期MS疲劳.
科学领域:
- 神经学 神经学
- 康复科学 康复科学 康复科学
- 运动生理学 运动生理学
背景情况:
- 疲劳是多发性硬化症 (MS) 的常见和致残症状,特别是在早期阶段.
- 缺乏早期多发性硬化症疲劳的有效管理策略.
- 在新诊断的多发性硬化症患者中,身体活动 (PA) 和疲劳之间的关系仍未得到充分探索.
研究的目的:
- 调查身体活动 (PA) 和久坐时间 (ST) 与新诊断MS (PNDwMS) 个体的疲劳之间的关联.
主要方法:
- 对47名PNDwMS参与者的二次数据分析 (诊断年龄<2年).
- 使用加速度计 (MVPA,LPA,ST,步骤/天) 进行7天的目标PA和ST测量.
- 疲劳通过疲劳严重程度表 (FSS) 进行评估;残疾通过患者确定的疾病阶段 (PDDS).
- 进行了两变相关性和渐进多重线性回归分析.
主要成果:
- 轻度体力活动 (LPA) 与疲劳严重程度 (FSS分数) 有显著的负相关性.
- 久坐时间 (ST) 和每天步骤也与FSS相关,但在回归中没有独立显著的意义.
- 即使在对残疾 (PDDS) 进行控制后,LPA仍然与较低疲劳 (FSS) 有显著的关联.
结论:
- 轻度体力活动 (LPA) 与新诊断为多发性硬化症的个体的疲劳有显著和逆相关性.
- 这些发现支持开发有针对性的行为干预措施,重点是增加LPA用于早期MS疲劳管理.
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