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在博障碍中对奖励产生更大的神经反应:与抑郁症和博严重性的关系
Maria Kryza-Lacombe1, Samantha V Abram2, Marc N Potenza3
1Mental Illness Research Education and Clinical Centers, Veterans Administration Medical Center, San Francisco, CA, USA; Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA.
概括
博障碍 (GD) 患者在奖励预期期间表现出高度的神经反应,特别是那些症状更严重的人. 这些夸张的大脑反应表明,改变奖励处理有助于这种行为成.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 行为成 行为成
背景情况:
- 博障碍 (GD) 是一种与奖励神经电路障碍相关的行为成.
- 在GD中的神经变化及其与包括抑郁症在内的临床症状的关系尚未完全理解.
研究的目的:
- 通过使用EEG,研究GD和健康对照者 (HCs) 之间的奖励处理中的神经差异.
- 检查神经反应,临床症状和GD中的功能之间的关系.
主要方法:
- 在老虎机任务期间,从参与者获得了GD (n=26) 和HC (n=54) 的EEG记录.
- 分析了与事件相关的潜在 (ERP) 组件,包括刺激前的消极性 (SPN),奖励积极性 (RewP) 和晚期的积极潜力 (LPP).
- 在GD组中,评估了奖励ERP与临床总结得分之间的关联.
主要成果:
- 与HC相比,GD参与者显示出较大的SPN幅度 (奖励预期) 和LPP幅度 (奖励结果评估).
- 在GD中,SPN幅度与较大的问题博和抑郁症状以及较低的全球功能显著相关.
- RewP幅度在各组之间没有差异,并且与临床严重程度无关.
结论:
- 患有GD的人在奖励预期 (SPN) 和结果处理 (LPP) 期间表现出夸张的神经反应.
- 对奖励预期的神经反应的增强在那些具有更严重临床表现的人群中尤为明显.
- 改变奖励预期和对结果的高度突出可能是博障碍背后的关键机制.
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