甲酸盐,酸盐和硫酸盐与氧化应激,炎症和肺部疾病的关联:来自全国代表性基于人口的研究的证据
Wei Liu1, Shuting Cao2, You Guo3
1Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China; School of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, China.
Environmental pollution (Barking, Essex : 1987)
|August 1, 2025
概括
暴露于酸盐和酸盐,以及联合暴露,与COPD和喘等肺部疾病的风险增加有关. 氧化应激和炎症可能在这些关联中起作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肺部医学 肺部医学
背景情况:
- 常见的环境化学物质如甲酸盐,酸盐和硫酸盐对呼吸系统健康的影响尚未完全理解.
- 氧化应激和炎症与各种肺部疾病的发展有关.
研究的目的:
- 调查尿液中甲酸盐,酸盐和硫酸盐的含量与肺部疾病的患病率之间的联系.
- 探索氧化应激和炎症生物标志物在这些关系中的潜在调解作用.
主要方法:
- 分析了国家健康和营养检查调查 (2007-2016) 中6978名成年人的数据.
- 利用调查加权回归和加权量素总和 (WQS) 回归来评估化学物质暴露和肺部疾病风险.
- 采用调解分析来评估生物标志物的影响,如总胆红素 (TBIL),γ-谷氨基转移酶,性酸酶和白细胞 (WBC) 计数.
主要成果:
- 增加的尿酸盐与患慢性阻塞性肺病 (COPD) 和肺气的风险更高有关.
- 尿中提酸盐的升高与COPD,肺气,慢性支气管炎和喘的风险增加相关.
- 对酸盐,酸盐和酸盐的联合暴露与COPD,肺气,慢性支气管炎和喘的风险增加有关.
- 总 bilirubin 部分抑制了化学疾病的关联,而中性粒细胞和白血细胞数量部分调解了它们.
结论:
- 尿中甲酸盐和硫酸盐的暴露与几种肺部疾病的患病率增加有关.
- 对这些化学物质的联合暴露也会增加肺部疾病的风险.
- 氧化应激和炎症途径,涉及TBIL和WBC等生物标志物,可能会调解化学物质暴露和肺部疾病之间的观察到的关联.
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