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Updated: Sep 13, 2025

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三甲酸通过诱导氧化应激会引起小鼠的葡萄糖不耐受和胰岛素耐药性

Rui Wang¹, Jie Chen¹, Pan Wang¹

¹Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|August 1, 2025

概括

有机化合物三正甲酸 (TOCP) 通过诱导氧化应激引起胰岛素耐药性和葡萄糖不耐受性. 抗氧化剂维生素C可能有助于减轻这些毒性影响.

科学领域:

毒理学毒理学毒理学
内分泌学在内分泌学.
代谢过程中的代谢.

背景情况:

三甲酸 (TOCP) 是一种常见的工业添加剂.
对TOCP对葡萄糖平衡的影响的确切机制尚不清楚.

研究的目的:

调查TOCP如何影响葡萄糖平衡和胰岛素抵抗.
阐明涉及氧化应激和葡萄糖载体的潜在机制.

主要方法:

在ICR小鼠中,对TOCP的次慢性暴露.
在体外实验中使用HepG-2细胞与TOCP代谢物CBDP进行实验.
评估血糖,胰岛素抵抗,氧化应激标志物和葡萄糖载体表达.
评估维生素C (Vc) 作为潜在的治疗剂.

主要成果:

在小鼠中,TOCP暴露导致高血糖症,胰岛素耐药性,肝氧化应激,以及改变葡萄糖输送物水平.
胰腺β细胞增生被观察到作为补偿反应.
在HepG-2细胞中,CBDP减少了胰岛素刺激的葡萄糖吸收,增加了活性氧物种.
在这两种模型中,与维生素C联合治疗改善了葡萄糖代谢障碍和氧化应激.

结论:

像TOCP这样的有机化合物可以诱导胰岛素抵抗和葡萄糖不耐受.
氧化应激是TOCP代谢毒性的关键机制.
维生素C显示出减轻有机化合物对葡萄糖代谢的不良影响的潜力.

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