相关实验视频

Updated: May 6, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

低剂量化物暴露会破坏人类和老鼠的CD4+T细胞平衡

Jing Zhou¹, Siqi Zhu¹, Yiyi Zhang¹

¹Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin Medical University, Harbin, 150081, Heilongjiang Province, China.

Environmental research

|August 1, 2025

概括

长期低剂量化物暴露,即使在安全范围内,也会通过改变CD4+T细胞子集和关键细胞因子来破坏适应性免疫力. 在T辅助1/T辅助2和T辅助1/T辅助17细胞中的这种不平衡可能会对长期健康产生影响.

科学领域:

免疫学免疫学免疫学
环境健康环境健康
毒理学毒理学毒理学

背景情况:

化物暴露,即使在世卫组织的安全限值 (≤1.5 mg/L) 中,也可能影响免疫功能.
CD4+ T 细胞介导的适应性免疫在宿主防御中起着至关重要的作用.
了解慢性低剂量化物对免疫特征的影响对于公共卫生至关重要.

研究的目的:

研究低剂量化物暴露对CD4+T细胞子集和适应性免疫的影响.
阐明化物诱导的免疫变化的潜在机制.
评估不同暴露时间和水利改善干预措施的影响.

主要方法:

使用飞行时间细胞计量 (CyTOF) 分析CD4+T细胞概况的人类研究.
集群和伪时间分析以确定免疫细胞子集和分化模式.
具有不同化物暴露水平和持续时间的老鼠模型,包括改善水的干预措施,以评估免疫反应和细胞因子表达.

主要成果:

在低和高暴露组之间观察到T助手1,T助手17,天真T和卵泡助手T细胞比例的显著差异.
长期暴露,即使是低到中等剂量,也改变了Th1/Th2和Th1/Th17的比率.
慢性化物暴露降低了Th1和Th2/Th17细胞因子 (IFN-γ,IL-2,IL-4,IL-17A),同时增加了IL-12p70,这表明Th1/Th2和Th1/Th17的不平衡.

结论:

长期低剂量化物暴露会通过改变CD4+T细胞的分布和功能而损害适应性免疫力.
化物通过调节IFN-γ,IL-2和IL-12p70等关键细胞因子来破坏免疫平衡.
改善水的干预措施对低剂量化物诱导的免疫变化产生了有限的恢复效应.

关键词:

免疫微环境是一个微环境.低化物含量的化物种群免疫特征种群免疫特征敏感的生物标志物敏感的生物标志物改善水资源的改善工作

更多相关视频

High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury

High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury

Published on: June 16, 2018

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

相关概念视频

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...