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在男性不孕症中,铁死是否令人担忧?
Bhagyalaxmi Sahoo1, Diptimayee Guru1, Anwesha Pradhan1
1Redox Biology and Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack 753003, India; Centre of Excellence in Environment and Public Health, Ravenshaw University, Cuttack 753003, India.
Reproductive toxicology (Elmsford, N.Y.)
|August 1, 2025
概括
铁亡是一种细胞死亡途径,涉及铁和脂质过氧化,显著影响男性生殖健康. 了解其机制对于解决男性不孕症和生殖功能障碍至关重要.
科学领域:
- 生殖生物学 生殖生物学
- 细胞死亡机制 细胞死亡机制
- 毒理学 毒理学 毒理学
背景情况:
- 男性的生殖健康正因氧化压力,环境因素和遗传问题而下降.
- 铁亡,细胞死亡过程,与男性生殖障碍有关.
- 关键因素包括氧化应激,活性氧物种 (ROS) 和表观遗传变化.
研究的目的:
- 审查铁死在男性生殖功能障碍中的作用.
- 探索将铁亡与男性不孕症联系起来的分子机制.
- 检查环境因素的影响和潜在的治疗策略.
主要方法:
- 文献综述,重点关注铁和男性生殖.
- 对涉及铁灭的分子途径的分析.
- 检查环境中有毒物质及其对丸健康的影响.
主要成果:
- 铁过载和脂质过氧化是铁亡的特征,导致丸损伤和精子生成受损.
- 环境的异生菌和与铁死相关的基因变化加剧了丸功能障碍.
- 脂质,铁和谷氨的代谢途径在ferroptosis诱导中至关重要.
结论:
- 铁亡是男性不孕症和生殖功能障碍的重要因素.
- 环境因素和遗传改变可以触发丸中的铁亡.
- 铁灭抑制剂显示出作为治疗男性不孕症的治疗剂的潜力.
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