Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Stress: General Loading Conditions01:15

Stress: General Loading Conditions

378
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
378
Components of Stress01:23

Components of Stress

277
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
277
Stress Concentrations01:24

Stress Concentrations

374
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
374
Applications of Stress01:04

Applications of Stress

403
Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
The...
403
Stresses under Combined Loadings01:23

Stresses under Combined Loadings

227
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
227
Stress-Strain Diagram01:10

Stress-Strain Diagram

837
A stress-strain diagram is a crucial tool that graphically displays a material's mechanical characteristics. This diagram is derived from a tensile test performed on a carefully prepared cylindrical specimen. The specimen has two gauge marks inscribed on its central part, and the distance between these marks is known as the gauge length. The cylindrical specimen is placed in a testing machine, which applies an increasing centric load. As this load grows, so does the gauge length. This...
837

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Towards a novel toxicity prediction pipeline, combining PBPK models and mechanistic cellular adversity models.

Toxicology·2026
Same author

Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA).

ALTEX·2026
Same author

ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors.

Chem·2026
Same author

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies.

Cellular oncology (Dordrecht, Netherlands)·2026
Same author

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing.

Environment international·2026
Same author

Quantitative adverse outcome pathway modeling of cisplatin-induced nephrotoxicity: developing in vitro and in vivo models for predictive extrapolation.

Toxicological sciences : an official journal of the Society of Toxicology·2026

相关实验视频

Updated: Sep 13, 2025

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.8K

数学建模揭示了特定化合物的应力路径活动.

Elsje J Burgers1, Tamara Y Danilyuk1, Raju P Sharma1

  • 1Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands.

Toxicology
|August 1, 2025
PubMed
概括

开发药物诱导性肝损伤 (DILI) 的数学模型揭示了细胞应激途径如何对有毒化合物作出反应. 该模型有助于预测药物开发期间的DILI风险.

关键词:
迪利迪利 (DILI) 是一个词.综合应激反应综合应激反应数学的建模数学建模氧化应激反应的反应是氧化应激反应.

更多相关视频

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.6K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K

相关实验视频

Last Updated: Sep 13, 2025

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.8K
A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.6K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K

科学领域:

  • 毒理学 毒理学 毒理学
  • 计算生物学 计算生物学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 药物诱导性肝损伤 (DILI) 在药物开发中带来了重大挑战.
  • 细胞应激通路的激活是潜在DILI的一个关键指标.
  • 了解这些途径对于预测药物毒性至关重要.

研究的目的:

  • 开发一个模拟细胞应激反应对DILI诱导化合物的数学模型.
  • 为了研究由尼特鲁福兰,迪克洛菲纳克和可纳引起的压力反应.
  • 分析在保存的压力路径内转录因子相互作用的差异.

主要方法:

  • 利用来自HepG2细胞的成像数据.
  • 测量了细胞相关化合物水平和细胞内谷氨.
  • 开发并重新校准了综合和氧化应激反应的数学模型.

主要成果:

  • 一个数学模型成功地开发并应用于三个DILI易受化合物.
  • 模型参数需要对不同化合物进行重新校准,但核心结构保持一致.
  • 分析显示,尽管类似的途径被激活,但转录因子相互作用的程度各不相同.

结论:

  • 开发的数学模型为理解DILI机制提供了一个框架.
  • 细胞对DILI化合物的应激反应可以通过定量建模.
  • 途径相互作用大小的差异突出了化合物特定的毒性概况.