视网膜的结构和解剖学变化是由于过量服用西尔德纳菲尔酸盐造成的
Rebika Dhiman1, Asmita Mahajan2, Vinay Gupta3
1Ophthalmology, All India Institute of Medical Sciences New Delhi, New Delhi, New Delhi, India drrebika@gmail.com.
BMJ case reports
|August 1, 2025
概括
过度摄入西尔代纳菲尔酸盐 (Viagra) 在一个年轻人身上导致视力问题,包括视力模糊和色彩困难. 这一案例凸显了未经医疗指导使用的固酶-5抑制剂对眼睛的毒性风险.
科学领域:
- 眼科医生 眼科 眼科
- 临床药理学 临床药理学
背景情况:
- 固酶-5抑制剂 (PDE5i),如西尔德纳菲尔,广泛用于治疗勃起功能障碍.
- 眼部的副作用,虽然很少见,可以发生在PDE5i使用.
研究的目的:
- 报告因西尔代纳菲尔过量服用引起的黄斑病例.
- 为了强调过度使用PDE5i的眼睛毒性潜力.
主要方法:
- 一名男性患者在摄入高剂量的西尔代纳菲尔酸盐后出现视力障碍的病例报告.
- 眼科检查包括视觉敏度,彩色视觉测试,自动周边测试和光学连贯断层扫描 (OCT).
主要成果:
- 患者表现出视力敏度下降,色彩和对比视力受损,双边中央视野缺陷.
- 海外国家和地区在斑点的圆形区域 (EZ) 和指际区域 (IZ) 发现了不规则.
- 在6个月内观察到色彩视觉和对比度灵敏度的部分恢复,视野缺陷持续存在,OCT发现几乎正常化.
结论:
- 不明智地使用西尔德纳菲尔可以导致显著的眼睛毒性,特别是黄斑病.
- 对于患者和医疗保健提供者来说,提高对固酶抑制剂过量剂量的风险的认识至关重要.
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