在患有系统性自身免疫和风湿性疾病的人群中,COVID-19疫苗增强吸收和有效性
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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
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Yonah C Ziemba1, Eric P Elkin2, Elham Kazemian3
1Y.C. Ziemba, MD, Department of Pathology and Laboratory Medicine, Northwell Health, New Hyde Park, New York, USA.
The Journal of rheumatology
|August 1, 2025
概括
COVID-19疫苗增强剂显著保护患有系统性自身免疫和类风湿性疾病 (SARD) 的个人免于住院治疗. 优先考虑增强剂的摄入对于这个高风险的免疫受损群体至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 患有系统性自身免疫和类风湿性疾病 (SARDs) 的个人通常免疫功能低下,增加他们患重症COVID-19的风险.
- 了解COVID-19疫苗接种的有效性,包括助推剂,对于保护这一脆弱人群至关重要.
研究的目的:
- 为了评估2019年冠状病毒病 (COVID-19) 提升剂量的吸收情况.
- 为了确定COVID-19助推剂的疫苗有效性 (VE) 在预防SARS患者中COVID-19住院治疗.
主要方法:
- 在四个美国卫生系统中,对接受疾病修饰性抗风湿药物的SARDs的成年患者进行了回顾性分析.
- 评估在2022年1月1日之前接收的单价增剂,以及在2022年9月1日至2023年8月31日期间接收的双价疫苗.
- 随访数据收集以评估与疫苗接种状态有关的COVID-19住院率.
主要成果:
- 在201165名SARD患者中,有63%接受了单价增剂. 单价增压剂显示,针对COVID-19住院治疗,调整后的VE为38%.
- 在246,991名SARD患者中,36%接受了双价疫苗. 双等效疫苗显示,针对COVID-19住院治疗的调整VE为32%.
- 单价增强剂和双价增强剂都提供了显著的保护,降低了这种免疫受损群体的住院率.
结论:
- 接种COVID-19复发疫苗有效地提供了针对SARD患者的严重COVID-19结果的大量保护.
- 增加COVID-19疫苗的增强剂量应该是这种高风险免疫受损人群的优先事项,以减轻严重的疾病.
- 这些发现强调了持续接种疫苗对免疫功能低下患者的重要意义.
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