刺激突发性和任务上下文编码在前扣膜-桃体-大脑关联学习网络中的编码
Jangjin Kim1, Hunter E Halverson2,3,4, John H Freeman5,4
1Department of Psychology, Kyungpook National University, Daegu, South Korea.
概括
前带状皮质,中枢杏仁体和小脑网络在学习过程中编码任务上下文和刺激偶然性. 突发事件的变化改变了这些大脑区域的神经元活动和同步.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 学习和记忆的学习和记忆
背景情况:
- 小脑 (CB) 与前脑系统的相互作用对于学习认知和运动任务至关重要.
- 追踪眼条件 (EBC) 是研究关联式学习和大脑相互作用的关键范式.
- 前环状皮质 (ACC),中枢杏仁体 (AM) 和CB对EBC至关重要.
研究的目的:
- 为了研究神经元活动和同步在ACC-AM-CB网络的变化如何在配对 (CS-US) 和灭绝 (CS-单独) 试验之间的过渡期间在痕迹眼条件.
- 要确定ACC-AM-CB网络是否编码了试验中的刺激应急情况和试验之间的任务背景.
主要方法:
- 在跟踪眼调节课期间,对来自老鼠的神经元活动数据的分析.
- 检查对和灭绝试验之间的过渡.
- 评估神经元同步和机器学习的行为预测.
主要成果:
- 所有三个区域 (ACC,AM,CB) 在刺激和试验间隔 (ITI) 期间都表现出神经元活动的变化,刺激意外性发生变化.
- 在ACC,AM和CB中神经元的子集在配对与灭绝试验期间表现出差异性活动.
- 与配对试验相比,神经元同步和机器学习对行为的预测在灭绝试验期间下降,这表明网络范围内的影响.
结论:
- 该ACC-AM-CB网络动态编码刺激应急情况和任务上下文.
- 应急情况的变化会影响神经元活动,同步和在这个网络中的行为预测.
- 过渡到灭绝可能会降低CB的纤维输入一致性,降低条件响应 (CRs) 的可能性.
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