素酸用于预防桃体切除术后的二次出血:从回顾性队列研究的见解
Somaya Koraysh1, Lina Naseralallah1, Zahra Noureddine1
1Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Clinical therapeutics
|August 1, 2025
概括
系统性三胺酸 (TXA) 并没有显著减少桃体切除术后出血 (PTB). 然而,在出院期间或出院后给予的TXA显著降低了PTB风险,这表明在桃体切除术后控制出血的潜在好处.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 外科手术的安全性
背景情况:
- 桃体切除术后出血 (PTB) 是一个严重的并发症,导致重复手术和死亡率.
- 胺酸 (TXA) 是一种抗纤维解质剂,用于在各种情况下控制出血.
- 系统性TXA在预防PTB方面的有效性尚不清楚.
研究的目的:
- 评估系统性 (静脉或口服) 松酸 (TXA) 在减少桃体切除术后的二次性出血 (PTB) 的疗效.
- 评估TXA对手术重新干预,输血,ICU入院和血红蛋白下降的需要的影响.
主要方法:
- 在卡塔尔的一家门诊护理中心进行的回顾性队列研究 (2021年1月 - 2024年1月).
- 分析包括2314名接受桃体切除术的患者.
- 使用奇平方和多逻辑回归分析来确定TXA使用与PTB发病率之间的关联.
主要成果:
- 在接受桃体切除术后TXA的患者和未接受的患者 (5.0%对3.9%,P=0.52) 之间,没有发现二次PTB发病率的显著差异.
- 使用TXA并没有显著降低PTB的几率 (OR 0.18,P=0.13).
- 然而,综合数据结合了手术内或出院TXA的使用,显著降低了PTB的几率 (OR 0.03,P=0.004).
结论:
- 在桃体切除术后给药的全身TXA并没有显著降低二次PTB发病率.
- 在使用TXA时,观察到减少手术重新干预的趋势.
- 联合手术内或出院TXA的使用显示PTB几率显著降低,需要在更大的研究中进一步调查.
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