患有1型糖尿病的新兴成年人中的COVID-19疫苗接种和态度
Colleen A Macke1, Samantha A Carreon1, Kishan R Desai1
1Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USA.
Vaccine
|August 1, 2025
概括
在患有1型糖尿病 (T1D) 的年轻人中,COVID-19疫苗接种率较低. 疫苗犹的原因包括怀疑,恐惧和外部因素,强调需要有针对性的干预措施.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 年轻人,特别是1型糖尿病 (T1D) 患者,与儿童和老年人相比,疫苗接种率较低.
- 患有T1D的人面临疫苗可预防疾病,包括COVID-19的严重并发症的风险增加.
- 由于SARS-CoV-2的风险增加,了解这一群体的COVID-19疫苗接种态度至关重要.
研究的目的:
- 评估T1D的年轻成年人在从儿科护理过渡期间接种COVID-19疫苗的情况.
- 确定和描述这一群体引用的导致COVID-19疫苗接种下降的主要原因.
主要方法:
- 参与过渡性干预试验的T1D (n=97) 的年轻成年人队列在基线报告了他们的COVID-19疫苗接种状态.
- 收集了人口统计和医疗数据,拒绝接种疫苗的参与者为他们的决定提供了定性理由.
- 通过专题分析,确定了疫苗犹的原因中的反复出现的主题.
主要成果:
- 70.1%的参与者报告至少接收了一剂COVID-19疫苗.
- 疫苗接种情况与人口统计或医疗特征之间没有发现显著的关联 (p ≥0.05).
- 拒绝接种疫苗的主要主题包括:对疫苗安全性/有效性的怀疑,对T1D不良影响的恐惧,外部因素和冷漠.
结论:
- 患有T1D的年轻人接种COVID-19疫苗不足以实现公共卫生目标.
- 解决关于疫苗对T1D的影响,疫苗开发和外部影响的具体问题对于临床医生与患者的对话至关重要.
- 需要进一步的研究来探索这种高风险群体对其他预防性健康措施的态度.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Insulin: Dosing Regimen and Adverse Effects
262
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
262
Diabetes: Management and Pharmacotherapy
386
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
386
Insulin Formulations: Types and Delivery
272
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
272
Diabetes: Symptoms, Diagnosis, and Complications
694
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
694


