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Updated: Sep 13, 2025

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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Published on: August 13, 2012

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结合 (R) -BPO-27的CFTR结构揭示了一个孔隙阻塞机制

Paul G Young1,2, Karol Fiedorczuk1, Jue Chen3,4

  • 1Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY, USA.

Nature communications
|August 1, 2025
PubMed
概括

选择性抑制囊性纤维化跨膜导电调节器 (CFTR) 是治疗分泌性腹和ADPKD等疾病的关键. 化合物 (R) -BPO-27阻断CFTR化孔,将离子流从ATP水解解脱开.

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