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Updated: Sep 13, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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USP17L通过对H2AK119ub1和ZSCAN4进行二氧化化促进了类似于2细胞的程序

Panpan Shi1,2, Xukun Lu3,4,5,6,7, Kairang Jin1,2

  • 1State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.

Nature communications
|August 1, 2025
PubMed
概括

USP17L基因家族,特别是USP17LE,通过二基因化H2AK119ub1来调节小鼠胚胎干细胞中的2C类状态,从而促进对囊基因组激活的关键基因表达.

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