婴儿肠道微生物群和SCFA调解了生命早期人乳微生物群与神经发育之间的关联
Simou Wu1, Wen Jia1, Jinxing Li1
1West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
NPJ biofilms and microbiomes
|August 1, 2025
概括
早期人乳微生物群 (HMM) 影响婴儿肠道微生物群 (IGM) 和神经发育. 稳定的HMM影响IGM和短链脂肪酸 (SCFA),可能防止神经发育问题.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 人类母乳微生物群 (HMM) 对婴儿肠道微生物群 (IGM) 的发展至关重要.
- 早期HMM对婴儿神经发育的长期影响尚不清楚.
研究的目的:
- 调查HMM发育及其对IGM神经发育交叉通话的影响.
- 探索IGM和SCFA在这种关系中的调解角色.
主要方法:
- 长度母婴队列研究.
- 在0日,7日和30日收集母乳和婴儿便样本进行测序和SCFA量化.
- 在12个月时使用ASQ-3进行神经发育评估.
主要成果:
- 在第一个月,HMM保持稳定,而IGM在前7天内显示出显著波动.
- 随着时间的推移,HMM,IGM和神经发育之间的关联得到了加强.
- IGM调解了HMM神经发育联系,SCFA在第30天调解了IGM神经发育联系.
结论:
- 早期稳定的HMM通过调节IGM和SCFA可能会影响长期的神经发育.
- 监测母婴微生态为预防神经发育障碍提供了一个潜在的策略.
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